ABSTRACT
Objective: To investigate the chemical constituents of Mallotus conspurcatus. Methods: The ethyl acetate part of 75% ethanol extracts from M. conspurcatus was separated through chromatographic techniques. The isolates were identified on the basis of 1H-NMR, 13C-NMR, and ESI-MS data. Results: Eighteen known compounds were isolated. They were 1,5-dihydroxy-3-methoxy-7- methyl-anthraquinon (1), (-)-syringaresinol (2), 2,3-dihydro-5,7-dihydroxy-2,8-dimethyl-6-(3-methyl-2-butenyl)-4H-1-benzo-4-one (3), 2,3-dihydro-5,7-dihydroxy-2,6,8-tri-methyl-4H-1-benzopyran-4-one (4), paeoveitol B (5), pinellic acid (6), trans-p- hydroxycinnamic acid (7), trans-p-methoxycinnamic acid (8), trans-p-hydroxy-ethyl cinnamate (9), p-hydroxybenzoic acid (10), 3-methoxy-4-hydroxybenzoic acid (11), 3,4-dihydroxybenzoic acid (12), ferulic acid (13), syringic acid (14), syringic acid ethyl ester (15), hexadecanoic acid 2,3-dihydroxy-propyl ester (16), galic acid (17), and ethyl gallate (18). Conclusion: Besides compounds 3, 4, and 13, the other compounds are isolated from the plants of Mallotus Lour. for the first time.
ABSTRACT
OBJECTIVE: To study the coumarins from Mallotus conspurcatus. METHODS: The ethyl acetate part of 75% ethanol extracts from Mallotus conspurcatus was isolated. The compounds were isolated and purified with column chromatography, and their structures were elucidated on the basis of 1H-NMR, 13C-NMR and ESI-MS data. RESULTS: Twelve coumarins were determined to be malloapelin A (1), 5'-demethyl aquillochin (2), aquillochin (3), cleomiscosin B (4), 6-hydroxy-7-methoxy-coumarin (5), braylin (6), aegelinol (7), bergapten (8), isofraxidin (9), fraxidin (10), grevillone (11), and fraxetin (12). CONCLUSION: Compounds 6-12 are isolated from this genus for the first time.